Capsaicin
Synonyms
6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (6E)-;
FEMA No. 3404;
Category
Non-ionic surfactant
> Phenol
>> Amide-group Phenol
Chemical Numbering System
CAS: 404-86-4
EINECS: 206-969-8
Molecular Formula & Molecular Weight
Molecular Formula: C18H27NO3; C18H27N1O3
Molecular Weight: 305.41
Structure
Properties
Appearance (1), solid.
Solubility insoluble in water.
Stability stable. Easily oxidized.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
rat intraperitoneal LD50 |
9.5mg/kg[1] |
|
mouse oral LD50 |
47.2mg/kg[1] |
|
mouse intravenous LD50 |
0.4mg/kg[1] |
|
guinea pig intraperitoneal LD50 |
1.1mg/kg[1] |
|
rabbit intraperitoneal LD50 |
> 50mg/kg[1] |
|
cat intravenous LDLo |
1.6mg/kg[1] |
|
hamster intraperitoneal LD50 |
> 120mg/kg[1] |
|
mouse intramuscular LD50 |
7.8mg/kg[1] |
|
mouse intraperitoneal LD50 |
6.5mg/kg[1] |
|
mouse intratracheal LD50 |
1.6mg/kg[1] |
|
mouse rectal LD50 |
> 218mg/kg[1] |
|
mouse skin LD50 |
> 512mg/kg[1] |
|
mouse subcutaneous LD50 |
9mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent anti-inflammatory, analgesic, dispersing, emulsifying abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as antioxidant.
2, Personal care products
Conditioning agent, masking agent in personal care products.
3, Agriculture
Use as insect repellent.
Manufacturers
References
[1]: ChemIDplus. 404-86-4, Capsaicin
Update: 20130916(1); 20190901(2)