Acetanilide
Synonyms
Acetamide, N-phenyl-;
Acetanilid;
Category
Non-ionic surfactant
> Amide
>> Aromatic Amides
Chemical Numbering System
CAS: 103-84-4
EINECS: 203-150-7
Molecular Formula & Molecular Weight
Molecular Formula: C8H9NO; C8H9N1O
Molecular Weight: 135.16
Structure
Properties
Appearance (1), white solid.
Solubility soluble in water; soluble in hot water.
Physical - chemical properties
|
Water solubility, g/L |
6.93 (25°C)[1] |
Stability stable. Under strong alkali condition, easily hydrolyzed.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
rat oral LD50 |
800mg/kg[2] |
|
mouse oral LD50 |
1210mg/kg[2] |
|
cat intravenous LDLo |
8.5mg/kg[2] |
|
cat oral LDLo |
250mg/kg[2] |
|
dog intravenous LDLo |
300mg/kg[2] |
|
dog oral LDLo |
500mg/kg[2] |
|
guinea pig oral LDLo |
200mg/kg[2] |
|
mouse intraperitoneal LD50 |
500mg/kg[2] |
|
rabbit oral LDLo |
1500mg/kg[2] |
|
rat intraperitoneal LD50 |
540mg/kg[2] |
Human Toxicity
Table 2 Human toxicity values
|
man oral TDLo |
405mg/kg[2] |
|
human oral TDLo |
14mg/kg/D[2] |
|
man oral LDLo |
56mg/kg/H-I[2] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent dispersing, emulsifying, analgesic, antipyretic abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), HG/T 2303 Acetanilide for industrial use
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as dispersing agent, emulsion stabilizer.
Use as hydrogen peroxide stabilizer.
2, Personal care products
Stabilizer, masking agent in personal care products.
3, Organic synthesis
Use as intermediate, for example, synthesis of azo dyes, photosensitive chemicals.
4, Polymer
Vulcanization accelerator in rubber industry.
Use as plasticizer.
Manufacturers
References
[1]: HSDB. 103-84-4, Acetanilide
[2]: ChemIDplus. 103-84-4, Acetanilide
Update: 20130916(1); 20190811(2);