Acetaminophen
Synonyms
Acetamide, N-(4-hydroxyphenyl)-;
Acetanilide, 4'-hydroxy-;
Category
Non-ionic surfactant
> Phenol
>> Amide-group Phenol
Chemical Numbering System
CAS: 103-90-2
EINECS: 203-157-5
Molecular Formula & Molecular Weight
Molecular Formula: C8H9NO2; C8H9N1O2
Molecular Weight: 151.16
Structure
Properties
Appearance (1), white solid.
Solubility soluble in water.
Stability stable. Under strong alkali condition, easily hydrolyzed.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
rat oral LD50 |
1944mg/kg[1] |
|
mouse oral LD50 |
338mg/kg[1] |
|
dog intravenous LDLo |
826mg/kg[1] |
|
dog oral LDLo |
2000mg/kg[1] |
|
frog subcutaneous LDLo |
50mg/kg[1] |
|
guinea pig oral LD50 |
2620mg/kg[1] |
|
mouse intraperitoneal LD50 |
367mg/kg[1] |
|
mouse subcutaneous LD50 |
310mg/kg[1] |
|
pig intravenous LDLo |
1000mg/kg[1] |
|
rat intraperitoneal LD50 |
1205mg/kg[1] |
Reproductive effect[1].
Human Toxicity
Table 2 Human toxicity values
|
child oral LDLo |
50mg/kg[1] |
|
infant oral TDLo |
1440mg/kg/6D[1] |
|
man oral LDLo |
714mg/kg[1] |
|
women oral LDLo |
400mg/kg[1] |
|
child oral LDLo |
360mg/kg/2D[1] |
|
child oral TDLo |
591mg/kg/2D-I[1] |
|
child oral TDLo |
801mg/kg[1] |
|
human oral LDLo |
143mg/kg[1] |
|
human oral LDLo |
357mg/kg[1] |
|
man oral LDLo |
143mg/kg/24H-[1] |
|
man oral TDLo |
9.286mg/kg[1] |
|
man oral TDLo |
714mg/kg[1] |
|
women oral LDLo |
260mg/kg[1] |
|
women oral LDLo |
650mg/kg[1] |
|
women oral TDLo |
4.962mg/kg[1] |
|
women oral TDLo |
13mg/kg[1] |
|
women oral TDLo |
325mg/kg[1] |
|
women oral TDLo |
490mg/kg[1] |
Overall carcinogenic evaluation: Group 3[1].
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent analgesic, antipyretic, dispersing, emulsifying abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2015 Edition) Paracetamol
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as dispersing agent.
Use as hydrogen peroxide stabilizer.
Use as intermediate. For example, used in synthesis of azo dyes, photosensitive chemicals.
2, Personal care products
Conditioning agent in personal care products.
3, Medicine
Use as pharmaceutical ingredient (antipyretic analgesics and non-steroidal anti-inflammatory drug). (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 103-90-2, Acetaminophen
Update: 20130916(1); 20190901(2)