Phenyl methyl pyrazolone
Synonyms
3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-;
3-Methyl-1-phenyl-5-pyrazolone;
Edaravone;
Category
Non-ionic surfactant
> Amine
>> Heteroaromatic Amine
>>> Pyrazole and its Derivatives
Chemical Numbering System
CAS: 89-25-8
EINECS: 201-891-0
Molecular Formula & Molecular Weight
Molecular Formula: C10H10N2O
Molecular Weight: 174.20
Structure
Properties
Appearance (1), solid.
Solubility slightly soluble in water; soluble in hot water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2, nitrogen oxides and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
dog intravenous LDLo |
600mg/kg[1] |
|
mouse intraperitoneal LD50 |
2012mg/kg[1] |
|
mouse intravenous LD50 |
588mg/kg[1] |
|
mouse oral LD50 |
1683mg/kg[1] |
|
mouse subcutaneous LD50 |
691mg/kg[1] |
|
rat intravenous LD50 |
631mg/kg[1] |
|
rat oral LD50 |
1915mg/kg[1] |
|
rat subcutaneous LD50 |
1101mg/kg[1] |
Reproductive effect[1].
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent anti-oxidizing, antistatic, antiedema, dispersing abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2020 Edition) Edaravone
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as antioxidant, free radical scavenger.
Use as antistatic agent.
Use as dispersing agent.
Use as intermediate in organic synthesis. For example, used in the synthesis of dyes.
2, Personal care products
Hair dyeing agent in personal care products.
Further information:
(1), In accordance with Safety and Technical Standards for Cosmetics (2015 Edition) of China, be included in the allowable hair dyeing agents.
Can be applied to oxidative hair dye products.
Maximum concentration is 0.25%.
(2), In accordance with EU regulations (EC) 2013/344, be included in Annex III/228.
Can be applied to oxidative hair dye products.
Maximum concentration is 0.25%.
3, Medicine
Use as pharmaceutical ingredient (free radical scavenger). (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 89-25-8, Edaravone
Update: 20200830(1);