Pramoxine HCl
Synonyms
Morpholine, 4-(3-(4-butoxyphenoxy)propyl)-, hydrochloride;
Morpholine, 4-(3-(p-butoxyphenoxy)propyl)-, hydrochloride;
Pramocaine hydrochloride;
Category
Non-ionic surfactant
> Amine
>> Heteroalicyclic Amine
>>> Morpholine and its Derivatives
Chemical Numbering System
CAS: 637-58-1
EINECS: 211-293-1
Molecular Formula & Molecular Weight
Molecular Formula: C17H28ClNO3; C17H27N1O3.HCl
Molecular Weight: 329.86
Structure
Properties
Appearance (1), solid.
Solubility soluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2, nitrogen oxides and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
guinea pig intravenous LDLo |
109mg/kg[1] |
|
mouse intraperitoneal LD50 |
460mg/kg[1] |
|
mouse intravenous LD50 |
79.5mg/kg[1] |
|
mouse oral LD50 |
1050mg/kg[1] |
|
mouse subcutaneous LD50 |
1470mg/kg[1] |
|
rabbit intravenous LD50 |
39mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antistatic, dispersing, emulsifying abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
90.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as emulsifying agent, dispersing agent.
Use as antistatic agent.
Use as pharmaceutical ingredient (For reference only.).
Manufacturers
References
[1]: ChemIDplus. 637-58-1, Pramoxine hydrochloride
Update: 20200808(1);