Block polyethylene-polypropylene glycol

Time: 2012-10-24 15:59:23; Count: 77

Block polyethylene-polypropylene glycol

Synonyms

Poloxamer;

Block polyoxyethylene-polyoxypropylene;

Oxirane, methyl-, polymer with oxirane, block;

Polyoxyethylene - polyoxypropylene block copolymer;

Category

Non-ionic surfactant

> Polyether

>> Ethylene Oxide - Propylene Oxide Homopolymer and Copolymer

Chemical Numbering System

CAS: 106392-12-5 / 9003-11-6 (generic)

EINECS: N/A / N/A

Molecular Formula & Molecular Weight

Molecular Formula: N/A

Molecular Weight: N/A

Structure

Properties

Appearance (1), colorless transparent liquid to white paste to white solid.

Solubility insoluble in water to soluble in water. Soluble in ethanol, toluene. Solubility is related to EO number, PO number.

Stability stable.

Risk Liquid (or solid) form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.

GHS label:

Animal Toxicity

Table 1 Animal toxicity values

mouse intraperitoneal LD50	420mg/kg^[1]
mouse intravenous LD50	129mg/kg^[1]
mouse intravenous LD50	1000mg/kg^[1]
mouse intravenous LD50	3000mg/kg^[1]
mouse oral LD50	> 30.3mg/kg^[1]
mouse oral LD50	1830mg/kg^[1]
mouse oral LD50	15000mg/kg^[1]
mouse subcutaneous LD50	5500mg/kg^[1]
rabbit skin LD50	> 5000mg/kg^[1]
rat intraperitoneal LD50	320mg/kg^[1]
rat intraperitoneal LD50	1140mg/kg^[1]
rat intravenous LD50	7500mg/kg^[1]
rat oral LD50	> 30.3mg/kg^[1]
rat oral LD50	2300mg/kg^[1]
rat oral LD50	5000mg/kg^[1]
rat oral LD50	9380mg/kg^[1]
rat oral LD50	22400mg/kg^[1]
rat subcutaneous LD50	6900mg/kg^[1]

Ecology may be hazardous to environment. Water body should be given special attention.

Biodegradability biodegradable.

Characteristics excellent cleansing, emulsifying, dispersing, solubilizing, lubricating, wetting, permeating, antistatic, antifoaming, demulsifying abilities. Performance is related to EO number, PO number. Low foaming. Resistance to non-oxidative acid.

Note (1), The by-product 1,4-dioxane is a possible carcinogen. Generally, can be acceptable when concentration of 1,4-dioxane is less than 30ppm or less.

(2), Be careful with using in children's products.

(3), Poloxamer (INCI Name) rules:

The first two digits in a three-digit number, multiplied by 100, indicates the approximate molecular weight of the hydrophobic part (PO). The last digit, multiplied by 10, indicates the approximate content of hydrophilic part (EO).

Synthesis

Obtained by polymerization of ethylene oxide and methyloxirane.

Quality Standards & Test Methods

1, Physical and chemical indexes

Item	Physical and chemical indexes
Item	Liquid/paste/solid
Actives, %, ≥	95.0

Test Methods

(1), Actives

GB/T 13173 Surface active agents -- Detergents -- Testing methods

2, Hazardous substances indexes

Item	Hazardous substances indexes
Item	Liquid/paste/solid
Heavy metals (as Pb), mg/kg, ≤	20
As, mg/kg, ≤	3

Test Methods

(1), Heavy metals (as Pb)

Safety and Technical Standards for Cosmetics (2015 Edition)

GB/T 30799 The test method of food detergents -- Determination of heavy metals

(2), As

Safety and Technical Standards for Cosmetics (2015 Edition)

GB/T 30797 The test method of food detergents -- Determination of total arsenic

3, Product standards

(1), Chinese standards

(1a), Chinese Pharmacopoeia (2015 Edition) Poloxamer 407

4, Further explanation

(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.

(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.

Major Uses

1, Typical applications

Use as cleansing agent.

Use as emulsifying agent, dispersing agent.

Use as solubilizing agent.

Use as lubricant.

Use as antifoaming agent.

2, Personal care products

Emulsifying agent, cleansing agent in personal care products.

3, Industrial cleaning

Cleansing agent, emulsifying agent, dispersing agent in industrial cleaning.

4, Machinery

Lubricant, coolant in metalworking fluids.

5, Food

Cleansing agent in food industry.

6, Polymer

Lubricant in rubber, resins.

7, Textile

Antistatic agent, peotective agent, wetting agent in textile, chemical fiber.

8, Petroleum

Demulsifying agent in crude oil.

9, Dye

Dispersing agent in pigments, dyes.

10, Papermaking

Defoaming agent in papermaking.

11, Agriculture

Emulsifying agent in pesticide.

12, Electroplating

Wetting agent in electroplating.

13, Medicine

Pharmaceutical excipient, use as solubilizing agent, emulsifying agent. (This section is for reference only, should be implemented according to local Pharmacopoeia.)

Product members

Poloxamer 101;

Poloxamer 105;

Poloxamer 108;

Poloxamer 122;

Poloxamer 123;

Poloxamer 124;

Poloxamer 181;

Poloxamer 182;

Poloxamer 183;

Poloxamer 184;

Poloxamer 185;