Benzoic acid, p-amino-, ethyl ester
Synonyms
Ethyl PABA;
Benzocaine;
Benzoic acid, 4-amino-, ethyl ester;
Category
Non-ionic surfactant
> Amine
>> Ester-group Amine
>>> Amino Acid Esters
Chemical Numbering System
CAS: 94-09-7
EINECS: 202-303-5
Molecular Formula & Molecular Weight
Molecular Formula: C9H11NO2; C9H11N1O2
Molecular Weight: 165.19
Structure
Properties
Appearance (1), solid.
Solubility slightly soluble in water. Soluble in ethanol.
Stability stable. Under strong acid or strong alkali condition, easily hydrolyzed.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2, nitrogen oxides and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intraperitoneal LD50 |
216mg/kg[1] |
|
mouse oral LD50 |
2500mg/kg[1] |
|
rabbit oral LDLo |
1150mg/kg[1] |
|
rat oral LD50 |
3042mg/kg[1] |
Human Toxicity
Table 2 Human toxicity values
|
infant rectal TDLo |
12mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent UV absorbing, dispersing, emulsifying, antistatic abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2020 Edition) Benzocaine
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as dispersing agent, emulsifying agent.
Use as UV absorbing agent.
2, Medicine
Use as pharmaceutical ingredient (local anaesthetics). (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 94-09-7, Benzocaine
Update: 20141015(1); 20200815(2);