Etidronate disodium
Synonyms
Disodium Etidronate;
Phosphonic acid, P,P'-(1-hydroxyethylidene)bis-, sodium salt (1:2);
Category
Anionic Surfactant
> Phosphonate
>> Hydroxyalkyl Phosphonate
>>> Hydroxy Linearalkyl Phosphonate
Chemical Numbering System
CAS: 7414-83-7
EINECS: 231-025-7
Molecular Formula & Molecular Weight
Molecular Formula: C2H6Na2O7P2; C2H8O7P2.2Na
Molecular Weight: 249.99
Structure
Properties
Appearance (1), solid.
Solubility soluble in water.
Stability stable.
Risk Solid form: irritation, irritation to skin, eye, respiratory system.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
dog intravenous LDLo |
32mg/kg[1] |
|
dog oral LDLo |
500mg/kg[1] |
|
mouse intraperitoneal LD50 |
250mg/kg[1] |
|
mouse intravenous LD50 |
49mg/kg[1] |
|
mouse oral LD50 |
1900mg/kg[1] |
|
mouse subcutaneous LD50 |
260mg/kg[1] |
|
rabbit oral LD50 |
581mg/kg[1] |
|
rat intravenous LD50 |
35mg/kg[1] |
|
rat oral LD50 |
1340mg/kg[1] |
|
rat subcutaneous LD50 |
372mg/kg[1] |
Reproductive effect[1].
Human Toxicity
Table 2 Human toxicity values
|
women oral TDLo |
240mg/kg/26W-[1] |
|
women oral TDLo |
240mg/kg/22W-[1] |
|
women oral TDLo |
588mg/kg/28W-[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent chelating, anticorrosive, dispersing, cleansing abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
90.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2015 Edition) Etidronate Disodium
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as chelating agent.
Use as anticorrosive agent.
2, Personal care products
Chelating agent in personal care products.
Further information:
(1), In accordance with EU regulations (EC) No 1223/2009, directive 89/174/EEC, etidronic acid and its salts are included in Annex III/53.
Can be applied:
(a), hair product: maximum concentration is 1.5% in leave-on products (as etidronic acid).
(b), soap: maximum concentration is 0.2% in leave-on products (as etidronic acid).
(2), In accordance with Safety and Technical Standards for Cosmetics (2015 Edition) of China, etidronic acid and its salts are the restricted components.
Can be applied:
(a), hair product: maximum concentration is 1.5% in leave-on products (as etidronic acid).
(b), soap: maximum concentration is 0.2% in leave-on products (as etidronic acid).
3, Water treatment
Chelating agent, scale inhibitor, corrosion inhibitor in water treatment.
4, Medicine
Use as pharmaceutical ingredient (Calcium regulatory agent). (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 7414-83-7, Etidronate disodium
Update: 20140330(1); 20190311(2);