Biotin
Synonyms
1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS,4S,6aR)-;
D-Biotin;
Category
Anionic Surfactant
> Carboxylate
>> Chain Carboxylate
>>> Thiophenimidazolyl Alkyl Carboxylate
>>>> Thiophenimidazolyl Linear Alkylcarboxylate
Chemical Numbering System
CAS: 58-85-5
EINECS: 200-399-3
Molecular Formula & Molecular Weight
Molecular Formula: C10H16N2O3S
Molecular Weight: 244.31
Structure
Properties
Appearance (1), colorless crystal.
Solubility slightly soluble in water.
Stability stable. Under strong alkali condition, easily hydrolyzed.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse oral LD50 |
> 10000mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent hair-growing, prevention of gray hair, prevention of hair loss, emulsifying, dispersing, solubilizing abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
GB/T 5173 Surface active agents and detergents -- Determination of anionic-active matter by direct two-phase titration procedure
ISO 2271 Surface active agents -- Detergents -- Determination of anionic-active matter by manual or mechanical direct two-phase titration procedure
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), GB 1903.25 Food safety national standard -- Food nutritional fortification substance -- D-Biotin
(1b), GB/T 23180 Feed additive -- 2% d-Biotin
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as micronutrient.
Use as emulsifying agent, dispersing agent.
2, Personal care products
Anti-seborrheic agent, conditioning agent in personal care products. Good conservation of skin, hair. Can promote hair growth. Can promote skin smooth.
3, Food
Use as food nutritional fortification substance.
4, Feed
Use as feed additive.
Manufacturers
References
[1]: HSDB. 58-85-5, Biotin
Update: 20140309(1); 20181008(2);