Glycyrrhizic Acid
Synonyms
Glycyrrhizinic acid;
alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-;
Category
Anionic Surfactant
> Carboxylate
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>>> Alicyclic Carboxylate
>>>> Pentacyclic Triterpene Carboxylate and its Derivatives
Chemical Numbering System
CAS: 1405-86-3
EINECS: 215-785-7
Molecular Formula & Molecular Weight
Molecular Formula: C42H62O16
Molecular Weight: 822.93
Structure
Properties
Appearance (1), white to pale yellow powder.
Solubility slightly soluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intravenous LD50 |
589mg/kg[1] |
|
mouse oral LD50 |
4320mg/kg[1] |
|
mouse intraperitoneal LDLo |
1000mg/kg[1] |
|
rat intravenous LD |
> 300mg/kg[1] |
|
rat intraperitoneal LDLo |
2000mg/kg[1] |
|
rat oral LDLo |
3000mg/kg[1] |
Human Toxicity
Table 2 Human toxicity values
|
human oral TDLo |
5.571mg/kg/3D-[1] |
|
human oral TDLo |
280mg/kg/4W[1] |
|
man oral TDLo |
662mg/kg/1Y-I[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent anti-inflammatory, anti-bacterial, anti-allergic, emulsifying, dispersing, solubilizing abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
90.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as emulsifying agent, dispersing agent.
Use as sweetener.
Use as antiallergic agent.
2, Personal care products
Conditioning agent, humectant in personal care products. Good anti-inflammatory, anti-allergic, detoxifying, whitening effects.
3, Food
Use as food additive (perfume).
Manufacturers
References
[1]: ChemIDplus. 1405-86-3, Glycyrrhizin
Update: 20140309(1); 20181029(2);