Carbenoxolone disodium
Synonyms
Olean-12-en-29-oic acid, 3-(3-carboxy-1-oxopropoxy)-11-oxo, disodium salt, (3beta,20beta)-;
Disodium Succinoyl Glycyrrhetinate;
Category
Anionic Surfactant
> Carboxylate
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>>> Alicyclic Carboxylate
>>>> Pentacyclic Triterpene Carboxylate and its Derivatives
Chemical Numbering System
CAS: 7421-40-1
EINECS: 231-044-0
Molecular Formula & Molecular Weight
Molecular Formula: C34H48Na2O7; C34H50O7.2Na
Molecular Weight: 614.72
Structure
Properties
Appearance (1), white to pale yellow powder.
Solubility soluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
rat subcutaneous LD50 |
1515mg/kg[1] |
|
rat oral LD50 |
2450mg/kg[1] |
|
rat intraperitoneal LD50 |
92mg/kg[1] |
|
mouse intravenous LD50 |
198mg/kg[1] |
|
mouse intraperitoneal LD50 |
120mg/kg[1] |
|
rabbit oral LD50 |
2000mg/kg[1] |
|
dog subcutaneous LD50 |
1060mg/kg[1] |
|
dog oral LD50 |
3900mg/kg[1] |
|
dog intravenous LD50 |
371mg/kg[1] |
|
dog intraperitoneal LD50 |
371mg/kg[1] |
Human Toxicity
Table 2 Human toxicity values
|
human oral TDLo |
120mg/kg/6W[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent anti-inflammatory, anti-bacterial, anti-allergic, emulsifying, dispersing, solubilizing abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
90.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as emulsifying agent, dispersing agent.
Use as antiallergic agent.
2, Personal care products
Conditioning agent, foam boosting agent in personal care products. Good anti-inflammatory, anti-allergic, detoxifying, whitening effects.
Manufacturers
References
[1]: ChemIDplus. 7421-40-1, Carbenoxolone sodium
Update: 20140309(1); 20181029(2);