Sodium thioglycolate
Synonyms
Acetic acid, 2-mercapto-, sodium salt (1:1);
Acetic acid, mercapto-, monosodium salt;
Sodium mercaptoacetate;
Thioglycolic acid, sodium salt;
Category
Anionic Surfactant
> Carboxylate
>> Chain Carboxylate
>>> Mercapto Alkyl Carboxylate
>>>> Mercapto Linear Alkyl Carboxylate
Chemical Numbering System
CAS: 367-51-1
EINECS: 206-696-4
Molecular Formula & Molecular Weight
Molecular Formula: C2H3NaO2S; C2H4O2S.Na
Molecular Weight: 114.10
Structure
Properties
Appearance (1), white to pale yellow powder.
Solubility soluble in water.
Stability stable. Easily oxidized.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
dog intravenous LDLo |
500mg/kg[1] |
|
monkey intravenous LDLo |
300mg/kg[1] |
|
mouse intraperitoneal LD50 |
200mg/kg[1] |
|
mouse intravenous LD50 |
422mg/kg[1] |
|
mouse oral LD50 |
504mg/kg[1] |
|
mouse subcutaneous LD50 |
293mg/kg[1] |
|
rabbit intravenous LDLo |
100mg/kg[1] |
|
rat intraperitoneal LD50 |
126mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent anti-oxidizing, dispersing, depilatory abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as antioxidant.
2, Personal care products
Epilating agent, hair waving or straightening agent, reducing agent, antioxidant in personal care products.
* * * * * *
Further information:
(1), In accordance with EU regulations (EC) No 1223/2009, directive 88/233/EEC, be included in Annex III/2a.
Can be applied to:
(1a), Hair products
General use: Maximum concentration is 8% (as thioglycolic acid), pH 7 to 9.5.
Professional use: Maximum concentration is 11% (as thioglycolic acid), pH 7 to 9.5.
(1b), Depilatories
Maximum concentration is 5% (as thioglycolic acid), pH 7 to 12.7.
(1c), Hair rinse-off products
Maximum concentration is 2% (as thioglycolic acid), pH 7 to 9.5.
(1d), Products intended for eyelash waving
Maximum concentration is 11% (as thioglycolic acid), pH 7 to 9.5.
(2), In accordance with Safety and Technical Standards for Cosmetics (2015 Edition) of China, be included in the restricted components.
Can be applied to:
(1a), Hair products
General use: Maximum concentration is 8% (as thioglycolic acid), pH 7 to 9.5.
Professional use: Maximum concentration is 11% (as thioglycolic acid), pH 7 to 9.5.
(1b), Depilatories
Maximum concentration is 5% (as thioglycolic acid), pH 7 to 12.7.
(1c), Hair rinse-off products
Maximum concentration is 2% (as thioglycolic acid), pH 7 to 9.5.
3, Leather
Tanning agent in leather.
Manufacturers
References
[1]: ChemIDplus. 367-51-1, Sodium thioglycolate
Update: 20140209(1); 20180917(2);