Calcium Gluconate
Synonyms
D-Gluconic acid, calcium salt (2:1);
Calcium D-Gluconate;
Category
Anionic Surfactant
> Carboxylate
>> Glycosyl Carboxylate
>>> Monosaccharide Acid and its Derivatives
Chemical Numbering System
CAS: 299-28-5
EINECS: 206-075-8
Molecular Formula & Molecular Weight
Molecular Formula: C12H22CaO14; C6H12O7.1/2Ca
Molecular Weight: 430.37
Structure
Properties
Appearance (1), white solid.
Solubility soluble in water. Dissolve slowly in cold water; dissolve quickly in hot water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
rat oral LD50 |
10000mg/kg[1] |
|
rat intravenous LD50 |
950mg/kg[1] |
|
mouse intravenous LD50 |
950mg/kg[1] |
|
mouse intraperitoneal LD50 |
2200mg/kg[1] |
Human Toxicity
Table 2 Human toxicity values
|
infant intramuscular TDLo |
143mg/kg[1] |
|
infant intramuscular LDLo |
10000mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent anticorrosive, dispersing, emulsifying, antirust abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), GB 15571 Food additive -- Calcium Gluconate
(1b), Chinese Pharmacopoeia (2015 Edition) Calcium Gluconate
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as dispersing agent.
2, Personal care products
Humectant, oral care agent, conditioning agent in personal care products.
3, Food
Use as food nutrition enhancer.
4, Medicine
Use as pharmaceutical ingredient (calcium supplement). (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 299-28-5, Calcium Gluconate
Update: 20140129(1); 20190225(2);