Glycyrrhizic acid, monoammonium salt
Synonyms
Ammonium glycyrrhizate;
alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, ammonium salt (1:1);
Category
Anionic Surfactant
> Carboxylate
>> Cyclic Carboxylate
>>> Alicyclic Carboxylate
>>>> Pentacyclic Triterpene Carboxylate and its Derivatives
Chemical Numbering System
CAS: 53956-04-0
EINECS: 258-887-7
Molecular Formula & Molecular Weight
Molecular Formula: C42H65NO16; C42H62O16.H3N
Molecular Weight: 839.96
Structure
Schematic formula:
Properties
Appearance (1), white to pale yellow solid.
Solubility soluble in water.
Stability stable. Under alkaline condition, ammonia is released.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
rat oral LD50 |
>10000mg/kg[1] |
|
rat intraperitoneal LD50 |
>300mg/kg[1] |
|
mouse oral LD50: |
9818mg/kg[1] |
|
mouse intravenous LD50 |
540mg/kg[1] |
|
mouse intraperitoneal LDLo |
1000mg/kg[1] |
Reproductive effect[1].
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent anti-inflammatory, anti-bacterial, anti-allergic, emulsifying, dispersing, solubilizing abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
70.0 |
|
pH (25°C, 1% solution) |
4.5 - 7.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
(2), pH
GB/T 6368 Surface active agents -- Determination of pH of aqueous solution - Potentiometric method
ISO 4316 Surface active agents -- Determination of pH of aqueous solutions -- Potentiometric method
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), GB 1886.242 Food safety national standard -- Food additive -- Ammonium glycyrrhizate
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as emulsifying agent, dispersing agent.
Use as sweetener.
Use as antiallergic agent.
2, Personal care products
Conditioning agent, masking agent in personal care products. Good anti-inflammatory, anti-allergic, detoxifying, whitening effects.
3, Food
Use as food additive (sweeting agent).
Manufacturers
References
[1]: ChemIDplus. 53956-04-0, Glycyrrhizic acid, monoammonium salt
Update: 20131114(1); 20181029(2);