Sucralfate
Synonyms
Aluminum, hexadeca-mu-hydroxytetracosahydroxy(mu8-(1,3,4,6-tetra-O-sulfo-beta-D-fructofuranosyl alpha-D-glucopyranoside tetrakis(hydrogen sulfato)(8-)))hexadeca-;
Aluminum sucrose octasulfate;
Category
Anionic Surfactant
> Sulfate
>> Sugar Sulfate
>>> Disaccharide Group Sulfate
>>>> Disaccharide Sulfate
Chemical Numbering System
CAS: 54182-58-0
EINECS: 259-018-4
Molecular Formula & Molecular Weight
Molecular Formula: C12H22O35S8.xAl
Molecular Weight: N/A
Structure
Schematic formula:
Properties
Appearance (1), white to slightly yellow powder.
Solubility slightly soluble in water; soluble in hydrochloric acid.
Hygroscopicity hygroscopic.
Stability stable in alkali, weak acid and hard water; unstable in strong acid, hydrolyzed.
Risk Solid form: irritation, irritation to skin, eye.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
rat oral LD50 |
>12000mg/kg[1] |
|
rat intraperitoneal LD50 |
>4000mg/kg[1] |
|
rat subcutaneous LD50 |
>4000mg/kg[1] |
|
mouse oral LD50 |
>8000mg/kg[1] |
|
mouse intraperitoneal LD50 |
>8000mg/kg[1] |
|
mouse subcutaneous LD50 |
>8000mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent dispersing, emulsifying abilities.
Synthesis
Sucrose and chlorosulfonic acid react, then react with aluminum chlorohydrate, finally obtain product.
US patent 4,990,610 (Method for preparing high potency sucralfate) presents a synthetic process.
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Aluminum content,%, ≥ |
15.0 - 25.0 |
|
Sulfur content,%, ≥ |
5.0 - 15.0 |
Test Methods
(1), Aluminum content
Chinese Pharmacopoeia (2015 Edition) Sucralfate
(2), Sulfur content
Chinese Pharmacopoeia (2015 Edition) Sucralfate
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2015 Edition) Sucralfate
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances; or furtherly test for microorganisms.
(c), Used in medicine, must comply with pharmacopoeia execution.
Major Uses
1, Typical applications
Use as dispersing agent, emulsion stabilizer.
2, Personal care products
Conditioning agent in personal care products.
3, Medicine
Use as pharmaceutical composition (anti-ulcer agent, antacid). (The contents of this section are for reference only and should be subject to medical advice.)
Manufacturers
References
[1]: ChemIDplus. 54182-58-0, Sucralfate
Update: 20130719(1); 20170220(2);