Penicillin G benzathine
Synonyms
Benzathine benzylpenicillin;
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)- (2S,5R,6R)-, compd. with N,N'-bis(phenylmethyl)-1,2-ethanediamine (2:1);
Category
Anionic Surfactant
> Carboxylate
>> Cyclic Carboxylate
>>> Lactam Carboxylate
>>>> Penicillin and its Derivatives
Chemical Numbering System
CAS: 1538-09-6
EINECS: 216-260-5
Molecular Formula & Molecular Weight
Molecular Formula: C48H56N6O8S2; C16H20N2.2C16H18N2O4S
Molecular Weight: 909.12
Structure
Properties
Appearance (1), solid.
Solubility very slightly soluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intraperitoneal LD50 |
460mg/kg[1] |
|
mouse oral LD50 |
2000mg/kg[1] |
Reproductive effect[1].
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antibacterial, antimicrobial, anti-infective abilities. beta-Lactam antibiotic. Long-acting penicillin.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2015 Edition) Benzathine benzylpenicillin
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as antibacterial agent, anti-infective agent.
2, Medicine
Use as pharmaceutical ingredient (beta-lactam antibiotic, penicillins). (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 1538-09-6, Penicillin G benzathine
Update: 20190107(1);