Oxytetracycline
Synonyms
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,6beta,12aalpha))-;
Terramycin;
Category
Non-ionic surfactant
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Chemical Numbering System
CAS: 79-57-2
EINECS: 201-212-8
Molecular Formula & Molecular Weight
Molecular Formula: C22H24N2O9
Molecular Weight: 460.43
Structure
Properties
Appearance (1), solid.
Solubility slightly soluble in water.
Physical - chemical properties
|
Water solubility, g/L |
0.313 (25 °C)[1] |
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
dog intravenous LDLo |
220mg/kg[2] |
|
guinea pig intraperitoneal LDLo |
2250mg/kg[2] |
|
mouse intraperitoneal LD50 |
5706mg/kg[2] |
|
mouse intravenous LD50 |
140mg/kg[2] |
|
mouse oral LD50 |
2240mg/kg[2] |
|
mouse subcutaneous LD50 |
700mg/kg[2] |
|
rat intravenous LD50 |
260mg/kg[2] |
|
rat oral LD50 |
4800mg/kg[2] |
Reproductive effect[1,2].
Human Toxicity
Table 2 Human toxicity values
|
infant parenteral TDLo |
136mg/kg[2] |
|
man oral TDLo |
114mg/kg/4D[2] |
|
women oral TDLo |
24mg/kg/6D-I[2] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antimicrobial, antibacterial, anti-infective abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as antibiotic.
Manufacturers
References
[1]: HSDB. 79-57-2, Oxytetracycline
[2]: ChemIDplus. 79-57-2, Oxytetracycline
Update: 20200718(1);