Hydrochlorothiazide
Synonyms
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide;
Category
Non-ionic surfactant
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>> Amido-group Amine
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Chemical Numbering System
CAS: 58-93-5
EINECS: 200-403-3
Molecular Formula & Molecular Weight
Molecular Formula: C7H8ClN3O4S2; C7H8Cl1N3O4S2
Molecular Weight: 297.74
Structure
Properties
Appearance (1), solid.
Solubility slightly soluble in water.
Physical - chemical properties
|
Water solubility, g/L |
0.722 (25°C)[1] |
Stability stable.
Risk Solid form: irritation, irritation to skin, eye, respiratory system.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
dog intravenous LD50 |
250mg/kg[2] |
|
mouse intraperitoneal LD50 |
578mg/kg[2] |
|
mouse intravenous LD50 |
590mg/kg[2] |
|
mouse oral LD50 |
1175mg/kg[2] |
|
mouse subcutaneous LD50 |
1470mg/kg[2] |
|
rabbit intravenous LD50 |
461mg/kg[2] |
|
rat intraperitoneal LD50 |
234mg/kg[2] |
|
rat intravenous LD50 |
990mg/kg[2] |
|
rat oral LD50 |
2750mg/kg[2] |
|
rat subcutaneous LD50 |
1270mg/kg[2] |
Overall carcinogenic evaluation: Group 2B (IARC).
Human Toxicity
Table 2 Human toxicity values
|
man oral TDLo |
12.857mg/kg/9D[2] |
|
man oral TDLo |
75mg/kg/30W-I[2] |
|
women oral LDLo |
2.5mg/kg/5D-[2] |
|
women oral TDLo |
0.25mg/kg[2] |
|
women oral TDLo |
0.5mg/kg[2] |
|
women oral TDLo |
2mg/kg/12H-I[2] |
|
women oral TDLo |
34.884mg/kg/30[2] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent diuretic, antihypertensive, dispersing, emulsifying, antistatic abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2020 Edition) Hydrochlorothiazide
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as pharmaceutical ingredient (diuretic, antihypertensive drug). (For reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: HSDB. 58-93-5, Hydrochlorothiazide
[2]: ChemIDplus. 58-93-5, Hydrochlorothiazide
Update: 20200822(1);