Clarithromycin
Synonyms
Erythromycin, 6-O-methyl-;
Category
Non-ionic surfactant
> Sugar-type
>> Aminosaccharide and its Derivatives
Chemical Numbering System
CAS: 81103-11-9
EINECS: N/A
Molecular Formula & Molecular Weight
Molecular Formula: C38H69NO13; C38H69N1O13
Molecular Weight: 747.95
Structure
Properties
Appearance (1), solid.
Solubility insoluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2, nitrogen oxide and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
dog oral LD |
> 5000mg/kg[1] |
|
mouse intraperitoneal LD50 |
850mg/kg[1] |
|
mouse intravenous LD50 |
173mg/kg[1] |
|
mouse oral LD50 |
1230mg/kg[1] |
|
mouse subcutaneous LD50 |
> 5000mg/kg[1] |
|
rat intraperitoneal LD50 |
669mg/kg[1] |
|
rat oral LD50 |
1270mg/kg[1] |
|
rat subcutaneous LD50 |
> 5000mg/kg[1] |
Human Toxicity
Table 2 Human toxicity values
|
women oral TDLo |
30mg/kg/3D-I[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antimicrobial, antibacterial, antistatic abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2015 Edition) Clarithromycin
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as antimicrobial agent, antibacterial agent.
2, Medicine
Use as pharmaceutical ingredient (macrolide antibiotics). (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 81103-11-9, Clarithromycin
Update: 20190929(1)