Ethambutol
Synonyms
1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, (R)-;
Category
Non-ionic surfactant
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Chemical Numbering System
CAS: 74-55-5
EINECS: 200-810-6
Molecular Formula & Molecular Weight
Molecular Formula: C10H24N2O2
Molecular Weight: 204.31
Structure
Properties
Appearance (1), solid.
Solubility soluble in water.
Stability stable.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2, nitrogen oxides and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intraperitoneal LD50 |
1075mg/kg[1] |
|
mouse intravenous LD50 |
240mg/kg[1] |
|
mouse oral LD50 |
8700mg/kg[1] |
|
rat oral LD50 |
998mg/kg[1] |
Human Toxicity
Table 2 Human toxicity values
|
human oral TDLo |
1410mg/kg/11W[1] |
|
man oral TDLo |
332mg/kg/31D-[1] |
|
man oral TDLo |
600mg/kg[1] |
|
man oral TDLo |
1200mg/kg[1] |
|
women oral TDLo |
900mg/kg/60D-[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antimicrobial, antibacterial, anti-infective, antitubercular, antistatic abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as pharmaceutical ingredient (antituberculous drug) (For reference only.).
Manufacturers
References
[1]: ChemIDplus. 74-55-5, Ethambutol
Update: 20200801(1);