Cyanocobalamin
Synonyms
Vitamin B12;
Cobinamide, cyanide phosphate 3'-ester with 5,6-dimethyl-1-alpha-D- ribofuranosylbenzimidazole, inner salt;
Category
Zwitterionic Surfactant
> Phosphate Type
Chemical Numbering System
CAS: 68-19-9
EINECS: 200-680-0
Molecular Formula & Molecular Weight
Molecular Formula: C63H88CoN14O14P
Molecular Weight: 1355.37
Structure
Properties
Appearance (1), solid.
Solubility soluble in water.
Physical - chemical properties
|
Water solubility, g/L |
12.5 (25°C)[1] |
Stability stable.
Risk Solid form: irritation, irritation to skin, eye, respiratory system.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse oral LD |
> 5000mg/kg[2] |
|
mouse intravenous LD50 |
2000mg/kg[2] |
|
mouse intraperitoneal LDLo |
1.364mg/kg[2] |
|
mouse subcutaneous LDLo |
2.727mg/kg[2] |
Reproductive effect[2].
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent emulsifying, dispersing, antistatic, solubilizing abilities. Excellent hematopoietic, growth-promoting abilities. Micronutrient. Should not be used with vitamin C, heavy metal salts at the same time.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
90.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2015 Edition) Vitamin B12
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as dispersing agent, emulsifying agent.
2, Personal care products
Conditioning agent in personal care products.
3, Medicine
Use as pharmaceutical ingredient (vitamins drug). (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: HSDB. 68-19-9, Cyanocobalamin
[2]: ChemIDplus. 68-19-9, Cyanocobalamin
Update: 20190701(1);