Rifampin
Synonyms
Rifamycin, 3-(((4-methyl-1-piperazinyl)imino)methyl)-;
Rifampicin;
Category
Non-ionic surfactant
> Amine
>> Heteroalicyclic Amine
>>> Lactam-group Heteroalicyclic Amine
Chemical Numbering System
CAS: 13292-46-1
EINECS: 236-312-0
Molecular Formula & Molecular Weight
Molecular Formula: C43H58N4O12
Molecular Weight: 822.94
Structure
Properties
Appearance (1), solid.
Solubility slightly soluble in water.
Physical - chemical properties
|
Water solubility, g/L |
1.4 (25 °C)[1] |
Stability stable. Unstable to light.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2, nitrogen oxides and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
guinea pig intraperitoneal LD50 |
639mg/kg[2] |
|
mouse intraperitoneal LD50 |
416mg/kg[2] |
|
mouse intravenous LD50 |
260mg/kg[2] |
|
mouse oral LD50 |
500mg/kg[2] |
|
mouse subcutaneous LD50 |
621mg/kg[2] |
|
rabbit oral LD50 |
2120mg/kg[2] |
|
rat intraperitoneal LD50 |
511mg/kg[2] |
|
rat oral LD50 |
1570mg/kg[2] |
|
rat subcutaneous LD50 |
534mg/kg[2] |
Reproductive effect[1].
Human Toxicity
Table 2 Human toxicity values
|
human oral TDLo |
180mg/kg[2] |
|
man oral LDLo |
857mg/kg[2] |
|
man oral TDLo |
13mg/kg/2D[2] |
|
man oral TDLo |
814mg/kg/15W-[2] |
|
women oral TDLo |
315mg/kg/5W-I[2] |
|
women oral TDLo |
504mg/kg/42D-[2] |
|
women oral TDLo |
744mg/kg/9W-I[2] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antimicrobial, antibacterial abilities. Macrocyclic lactam antibiotics.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2020 Edition) Rifampicin
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as pharmaceutical ingredient (antituberculous drug). (For reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: HSDB. 13292-46-1, Rifampin
[1]: ChemIDplus. 13292-46-1, Rifampin
Update: 20200808(1);