Oxprenolol hydrochloride
Synonyms
Oxprenolol HCl;
2-Propanol, 1-(o-allyloxyphenoxy)-3-isopropylamino-, hydrochloride;
Category
Non-ionic surfactant
> Amine
>> Ether-group Amine
>>> Ether-group Chain Amine
>>>> Aryloxy Alcohol Amine
Chemical Numbering System
CAS: 6452-73-9
EINECS: 229-260-5
Molecular Formula & Molecular Weight
Molecular Formula: C15H24ClNO3; C15H23N1O3.HCl
Molecular Weight: 301.81
Structure
Properties
Appearance (1), solid.
Solubility soluble in water.
Stability stable. Easily oxidized.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2, nitrogen oxides and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intraperitoneal LD50 |
170mg/kg[1] |
|
mouse intravenous LD50 |
20mg/kg[1] |
|
mouse oral LD50 |
520mg/kg[1] |
|
mouse subcutaneous LD50 |
245mg/kg[1] |
|
dog intravenous LD50 |
15mg/kg[1] |
|
dog oral LDLo |
> 30mg/kg[1] |
|
dog subcutaneous LDLo |
> 30mg/kg[1] |
|
rabbit intravenous LDLo |
20mg/kg[1] |
|
rat intraperitoneal LD50 |
147mg/kg[1] |
|
rat intravenous LD50 |
33mg/kg[1] |
|
rat oral LD50 |
214mg/kg[1] |
|
rat subcutaneous LD50 |
940mg/kg[1] |
Human Toxicity
Table 2 Human toxicity values
|
women oral LDLo |
90mg/kg[1] |
|
women oral TDLo |
160mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent anti-anxiety, anti-arrhythmia, antihypertensive, antistatic, dispersing abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as pharmaceutical ingredient (beta-adrenergic receptor blocker). (For reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 6452-73-9, Oxprenolol hydrochloride
Update: 20200822(1);