Dexamethasone
Synonyms
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16alpha)-;
Category
Non-ionic surfactant
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Chemical Numbering System
CAS: 50-02-2
EINECS: 200-003-9
Molecular Formula & Molecular Weight
Molecular Formula: C22H29FO5; C22H29F1O5
Molecular Weight: 392.46
Structure
Properties
Appearance (1), solid.
Solubility slightly soluble in water.
Stability stable. Easily oxidized.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intraperitoneal LD50 |
410mg/kg[1] |
|
mouse subcutaneous LD50 |
4400mg/kg[1] |
|
rabbit subcutaneous LD50 |
7.2mg/kg[1] |
|
rat intraperitoneal LD50 |
54mg/kg[1] |
|
rat oral LD50 |
> 3000mg/kg[1] |
|
rat subcutaneous LD50 |
14mg/kg[1] |
Reproductive effect[1].
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent anti-inflammatory, anti-allergic, emulsifying, dispersing, lubricating abilities. Glucocorticoid.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2015 Edition) Dexamethasone
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as anti-inflammatory agent.
Use as emulsifying agent, dispersing agent.
Use as lubricant.
2, Medicine
Use as pharmaceutical ingredient (adrenal cortex hormone). (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 50-02-2, Dexamethasone
Update: 20190922(1)