Phenobarbital sodium
Synonyms
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-phenyl-, monosodium salt；
Barbituric acid, 5-ethyl-5-phenyl-, sodium salt;
Category
Anionic Surfactant
> Alkoxide
Chemical Numbering System
CAS: 57-30-7
EINECS: 200-322-3
Molecular Formula & Molecular Weight
Molecular Formula: C12H11NaN2O3; C12H12N2O3.Na
Molecular Weight: 254.22
Structure
Properties
Appearance (1), solid.
Solubility soluble in water.
Stability stable. Easily hydrolyzed.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Animal Toxicity
Table 1 Animal toxicity values
|
cat oral LD50 |
175mg/kg[1] |
|
guinea pig intraperitoneal LDLo |
150mg/kg[1] |
|
mouse intraperitoneal LD50 |
123mg/kg[1] |
|
mouse intravenous LD50 |
226mg/kg[1] |
|
mouse oral LD50 |
200mg/kg[1] |
|
mouse subcutaneous LD50 |
180mg/kg[1] |
|
rabbit intraperitoneal LD50 |
150mg/kg[1] |
|
rabbit intravenous LD50 |
40mg/kg[1] |
|
rabbit oral LD50 |
150mg/kg[1] |
|
rat intraperitoneal LD50 |
152mg/kg[1] |
|
rat intravenous LD50 |
83mg/kg[1] |
|
rat oral LD50 |
150mg/kg[1] |
|
rat subcutaneous LD50 |
195mg/kg[1] |
|
rat intraduodenal LDLo |
100mg/kg[1] |
Reproductive effect[1].
Human Toxicity
Table 2 Human toxicity values
|
man oral TDLo |
36mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent hypnotic, sedative abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2015 Edition) Phenobarbital sodium
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as pharmaceutical ingredient. (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers
References
[1]: ChemIDplus. 57-30-7, Phenobarbital sodium
Update: 20180826(1);