Amobarbital sodium

Amobarbital sodium

Synonyms

2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-(3-methylbutyl)-, monosodium salt;

Barbituric acid, 5-ethyl-5-isopentyl-, sodium salt;

Category

Anionic Surfactant

> Alkoxide

Chemical Numbering System

CAS: 64-43-7

EINECS: 200-584-9

Molecular Formula & Molecular Weight

Molecular Formula: C11H17NaN2O3; C11H18N2O3.Na

Molecular Weight: 248.25

Structure

Properties

Appearance    (1), solid.

Solubility    soluble in water.

Stability    stable. Easily hydrolyzed.

Risk    Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.

GHS label:  

Animal Toxicity

Table 1 Animal toxicity values

cat intraperitoneal LDLo	90mg/kg[1]
cat intravenous LDLo	60mg/kg[1]
dog intravenous LD50	75mg/kg[1]
dog oral LD50	99mg/kg[1]
dog rectal LDLo	200mg/kg[1]
frog oral LDLo	110mg/kg[1]
guinea pig intraperitoneal LDLo	120mg/kg[1]
guinea pig intravenous LDLo	90mg/kg[1]
guinea pig subcutaneous LDLo	170mg/kg[1]
mouse intraperitoneal LD50	200mg/kg[1]
mouse oral LD50	505mg/kg[1]
mouse subcutaneous LD50	200mg/kg[1]
mouse intravenous LDLo	200mg/kg[1]
rabbit intraperitoneal LD50	90mg/kg[1]
rabbit intravenous LD50	70mg/kg[1]
rabbit oral LD50	575mg/kg[1]
rabbit subcutaneous LDLo	110mg/kg[1]
rat intravenous LD50	128mg/kg[1]
rat oral LD50	275mg/kg[1]
rat intraperitoneal LDLo	120mg/kg[1]
rat subcutaneous LDLo	90mg/kg[1]

Ecology    may be hazardous to environment. Water body should be given special attention.

Biodegradability    biodegradable.

Characteristics    excellent hypnotic, sedative abilities.

Synthesis

 

Quality Standards & Test Methods

1, Physical and chemical indexes

Item	Physical and chemical indexes
	Solid
Actives, %, ≥	95.0

Test Methods

(1), Actives

 

2, Hazardous substances indexes

Item	Hazardous substances indexes
	Solid
Heavy metals (as Pb), mg/kg, ≤	20
As, mg/kg, ≤	3

Test Methods

(1), Heavy metals (as Pb)

Safety and Technical Standards for Cosmetics (2015 Edition)

GB/T 30799 The test method of food detergents -- Determination of heavy metals

(2), As

Safety and Technical Standards for Cosmetics (2015 Edition)

GB/T 30797 The test method of food detergents -- Determination of total arsenic

3, Product standards

(1), Chinese standards

(1a), Chinese Pharmacopoeia (2015 Edition) Amobarbital sodium

4, Further explanation

(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.

Major Uses

1, Typical applications

Use as pharmaceutical ingredient. (This section is for reference only, should be implemented according to local Pharmacopoeia.)

Manufacturers

 

References

[1]: ChemIDplus. 64-43-7, Amobarbital sodium

Update: 20180826(1);