Pentobarbital sodium

Pentobarbital sodium

Synonyms

2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-(1-methylbutyl)-, monosodium salt;

Barbituric acid, 5-ethyl-5-(1-methylbutyl)-, sodium salt;

Category

Anionic Surfactant

> Alkoxide

Chemical Numbering System

CAS: 57-33-0

EINECS: 200-323-9

Molecular Formula & Molecular Weight

Molecular Formula: C11H17NaN2O3; C11H18N2O3.Na

Molecular Weight: 248.25

Structure

Properties

Appearance    (1), solid.

Solubility    soluble in water.

Stability    stable. Easily hydrolyzed.

Risk    Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.

GHS label:  

Animal Toxicity

Table 1 Animal toxicity values

cat oral LD50	100mg/kg[1]
cat intraperitoneal LDLo	70mg/kg[1]
chicken intraperitoneal LD50	51.54mg/kg[1]
chicken intravenous LD50	48mg/kg[1]
dog oral LD50	65mg/kg[1]
dog intraperitoneal LDLo	50mg/kg[1]
dog intravenous LDLo	50mg/kg[1]
duck oral LD50	75mg/kg[1]
guinea pig intramuscular LD50	70.3mg/kg[1]
guinea pig oral LD50	60mg/kg[1]
guinea pig subcutaneous LD50	70mg/kg[1]
guinea pig intraperitoneal LDLo	56mg/kg[1]
mouse intracerebral LD50	6.5mg/kg[1]
mouse intramuscular LD50	124mg/kg[1]
mouse intraperitoneal LD50	126mg/kg[1]
mouse intravenous LD50	81mg/kg[1]
mouse oral LD50	239mg/kg[1]
mouse subcutaneous LD50	122mg/kg[1]
pigeon oral LD50	133mg/kg[1]
rabbit intraperitoneal LD50	65mg/kg[1]
rabbit intravenous LD50	40mg/kg[1]
rabbit oral LD50	175mg/kg[1]
rabbit parenteral LDLo	60mg/kg[1]
rabbit rectal LDLo	65mg/kg[1]
rat intraduodenal LD50	39mg/kg[1]
rat intraperitoneal LD50	36mg/kg[1]
rat intravenous LD50	65mg/kg[1]
rat oral LD50	118mg/kg[1]
rat subcutaneous LD50	47mg/kg[1]
rat intravenous LDLo	80mg/kg[1]

Reproductive effect^[1].

Human Toxicity

Table 2 Human toxicity values

man oral TDLo	6.43mg/kg[1]
women oral TDLo	60mg/kg[1]

Ecology    may be hazardous to environment. Water body should be given special attention.

Biodegradability    biodegradable.

Characteristics    excellent hypnotic, sedative abilities.

Synthesis

 

Quality Standards & Test Methods

1, Physical and chemical indexes

Item	Physical and chemical indexes
	Solid
Actives, %, ≥	95.0

Test Methods

(1), Actives

 

2, Hazardous substances indexes

Item	Hazardous substances indexes
	Solid
Heavy metals (as Pb), mg/kg, ≤	20
As, mg/kg, ≤	3

Test Methods

(1), Heavy metals (as Pb)

Safety and Technical Standards for Cosmetics (2015 Edition)

GB/T 30799 The test method of food detergents -- Determination of heavy metals

(2), As

Safety and Technical Standards for Cosmetics (2015 Edition)

GB/T 30797 The test method of food detergents -- Determination of total arsenic

3, Further explanation

(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.

Major Uses

1, Typical applications

Use as reagent.

Manufacturers

 

References

[1]: ChemIDplus. 57-33-0, Pentobarbital sodium

Update: 20180826(1);