Bromelain
Synonyms
EC 3.4.22.4;
Category
Special Surfactant
> Enzyme
Chemical Numbering System
CASRN：9001-00-7
EINECS：232-572-4
Molecular Formula & Molecular Weight
Molecular Formula: N/A
Molecular Weight: N/A
Structure
Properties
Appearance (1), white to brown-yellow amorphous powder.
Solubility soluble in water.
Stability stable.
Risk Solid form: irritation, irritation to skin, eye, respiratory system.
GHS (Rev.10) label: 
Animal Toxicity
Table 1 Animal toxicity values
|
mouse intraperitoneal LD50 |
36.7mg/kg[1] |
|
mouse intravenous LD50 |
30mg/kg[1] |
|
mouse oral LD50 |
> 10000mg/kg[1] |
|
rabbit intravenous LD50 |
20mg/kg[1] |
|
rat intraperitoneal LD50 |
85.2mg/kg[1] |
|
rat oral LD50 |
> 10000mg/kg[1] |
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent catalytic, anti-inflammatory abilities. Thiol protease.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Enzyme activity, U, ≥ |
|
Test Methods
(1), Enzyme activity
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Heavy metals (as Pb), mg/Kg, ≤ |
30 |
|
As, mg/Kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
GB 5009.74 Food safety national standard -- Method for limit test of heavy metals in food additives
GB 5009.12 Food safety national standard -- Determination of lead in foods
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents - Determination of heavy metals
(2), As
GB 5009.11 Food safety national standard -- Determination of total arsenic and abio-arsenic in foods
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents - Determination of total arsenic
3, Further explanation
(a), Used in cosmetics, should be test for harmful substances; or furtherly test for microorganisms.
Major Uses
1, Typical applications
Use as catalyst.
2, Personal care products
Conditioning agent, keratolytic agent in personal care products.
3, Food
Use as food additive.
Manufacturers
References
[1]: ChemIDplus. 9001-00-7, Bromelain
Update: 20180815(1);